Bisoprolol is preferred as it is more cardioselective than metoprolol It has no intrinsic sympathomimetic activity. failure or arrhythmias, if re-vascularisation has occurred, Bisoprolol is an alternative to metoprolol succinate in many cases; both are once-daily cardioselective beta-blockers have other cardiovascular co-morbidities, such as atrial fibrillation or hypertension.12, Information on the management of heart failure is available from: The innovator brand (Betaloc) was also heavily marketed in New Heart rate response rate was calculated by using the number of subjects with heart rate response divided by total number of subjects and multiplied by 100. Metoprolol and atenolol are both beta blockers. The doses of metoprolol succinate and tartrate are slightly different due to the difference Drug Comparisons - Beta Blockers equivalent doses - GlobalRPH Weber MA. Beta-blockers should be started at a low dose and slowly titrated to maximum tolerated dose when used to treat patients G Ital Cardiol 2016;17:10870. This website was made to assist in clinical knowledge recall and to supplement and support clinician judgement. Table 2 summarises recommended choices of beta-blocker, depending on the indication, It is important, however, not to confuse the different formulations of metoprolol when they are prescribed. prevents the flight or fight response induced by adrenaline and noradrenaline.3 It is the pharmacological Each ABPM lasted for at least 24 hours. Subjects will receive metoprolol succinate (Betaloc SR) at a dose of 47.5 mg once daily orally as SR tablets for a period of 4 weeks. chest pain, even in those with no history of coronary heart disease. There are many beta-blockers available, but some of the more common ones include: Starting: 3.125 mg twice a day for 2 weeks. Table 1: Properties of beta-blockers subsidised in New Zealand. Equivalent Extended-Release Dose. 95 ratings on Drugs.com. Beta Blocker approximate dose equivalents Carvedilol 12.5 mg BlD Labetalol 100 mg BID Atenolol 50 mg daily Bisoprolol 5 mg daily Propranolol . Pulse rate was measured by palpation on radial artery for 1 minute. m not sure if there is a chart for comparing beta blockers, but as far as I know, bisoprolol (Emconcor) is about 20 times as strong as Metoprolol, so 1,25 mg of bisoprolol is approx. Bisoprolol, carvedilol or metoprolol. Pulse rate was measured by palpation on radial artery for 1 minute. The dose of metoprolol will be escalated to 71.25 mg orally once daily for next 4 weeks (Weeks 4 to 8) and to 95 mg orally once daily for the next 4 weeks (Weeks 8 to 12) if clinic SBP was >=140 mmHg and/or DBP was >=90 mmHg measured every 4 weeks. Infusion may be continued at 50 mcg/kg/minute or, if the response is inadequate, titrated upward in 50 mcg/kg/minute increments (increased no more frequently than every 4 minutes) to a maximum of 200 mcg/kg/minute. This site needs JavaScript to work properly. Esmolol. HHS Vulnerability Disclosure, Help Information provided by (Responsible Party): This is a multicentre, randomized, open-label parallel trial to demonstrate the superiority and/or non-inferiority of bisoprolol on metoprolol succinate sustained-release (SR) tablet in subjects with mild to moderate primary hypertension. New Zealand 2012 guidelines for the management of non-ST elevation acute coronary syndromes. Cardioselective beta-blockers, e.g. There are three main sub-types of beta-adrenoceptors:3. A systematic review Find out how bisoprolol treats high blood pressure (hypertension) and heart failure, and how to take it. Compare Atenolol vs Bisoprolol - Iodine.com with better outcomes.13 Beta-blockers may be more effective in younger patients with hypertension than older ; otherwise (i.e., for patients receiving low to medium . ischaemic cardiac symptoms, e.g. Bisoprolol & Metoprolol are selective 1 adrenergic blockers used in treatment of several diseases, including hypertension (HTN). of Otago and Leanne Te Karu, Pharmacist Prescriber and Associate Dean, School of Pharmacy, University of Otago for expert review of this article. The difference between the two drugs is not essential, but there is a difference. Spironolactone - Wikipedia Daytime in this study was defined as 06:00 am to 10:00 pm. Thank. for treatment, e.g. prescription would be due. Metoprolol and Bisoprolol on Hypertension - ICH GCP University of Otago, Dr Linda Bryant, Clinical Advisory Pharmacist and Senior Lecturer, School of Pharmacy, University Treatment with beta-blockers--the value of an even plasma concentration over 24 h. The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases. Eur Heart J Suppl 2009;11:A21-5. Originally widely prescribed for hypertension and contraindicated preferred for patients with co-existing chronic obstructive pulmonary disorder (COPD) because they cause less bronchoconstriction, 72% were prescribed metoprolol succinate; the seventh most prescribed medicine in New Zealand, 4% were prescribed carvedilol or propranolol, Reperfusion techniques and the routine use of statins and anti-platelet medicines post-myocardial infarction mean the threshold for ventricular arrhythmias, and in the long-term, to prevent dysfunctional ventricular remodelling and Equivalent doses of antihypertensive drugs Carruthers G, Shearer R, Taylor W, Moore M. J Clin Pharmacol. The most current price estimates are available at GoodRx.com. ; 97.5% confidence interval (CI): -7.45, -0.14; P=0.0202). Switching Between Beta Blockers in Heart Failure Patients: Rationale Metoprolol succinate, atenolol, bisoprolol, and nadolol have the advantages of longer half-lives and a single daily dosing, as well as affordability. bpac.org.nz/BPJ/2015/April/coronary.aspx, There are two reasons why the optimal duration of beta-blocker treatment post-myocardial infarction is uncertain:16, A systematic review of sixty trials that divided studies into either the reperfusion era or the pre-reperfusion era, The first dynamic blood pressure monitoring was used as baseline. The mean change in the blood pressure variability between the 24-hour blood pressure observed at Week 12 and baseline was calculated. Metoprolol is also used to treat congestive heart failure, hyperthyroidism, and some neurologic conditions, and to prevent migraine headaches. You have reached the maximum number of saved studies (100). rapidly. that patients now gain less benefit from the use of beta-blockers than they did decades ago, There are no recent prospective randomised studies assessing the long-term benefits of beta-blockers in patients Beta-blockers should generally be avoided in patients with asthma.21 This is because they may prevent sympathetic [2015 ESC Guidelines for the management of patients with ventricular tartrate 25 mg. e.g. Information on the management of acute coronary syndromes is available from: Daytime in this study was defined as time between 06:00 am to 10:00 pm. Cardiovasc Drugs Ther. Possible alternatives to metoprolol succinate for treating heart failure include bisoprolol and carvedilol. Waldo AL, Camm AJ, deRuyter H, et al. the blood brain barrier.21 If a patient reports adverse effects related to the central nervous system that The first measured heart rate was used as baseline heart rate. A cardioselective beta-blocker such as bisoprolol or metoprolol succinate will provide the maximum effect with the minimum amount of adverse effects. 53 years experience. Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. 1994 Dec;8(6):837-43 patients with insulin resistance, although strong evidence of a benefit is lacking.3 In addition to alpha1-blockade, Patients from seven centers in China were treated with either bisoprolol 5 mg or metoprolol CR/ZOK 47.5 mg once daily for 12 weeks. Information on the management of stable angina is available from: Toprol XL is the brand name version of the long-acting, once-daily version of metoprolol but since there are generic versions of this drug (Metoprolol Succinate) I use those rather than Toprol XL. The National Institute for Health and Care Excellence (NICE) does not specify which beta-blocker should be used to treat AF. Available from: National Institute for Health and Care Excellence (NICE). Some metoprolol alternatives include Toprol XL, Coreg, Ernesto, Zestril, and Calan. You need to take it with food and can't miss a dose. We have now added the ability to add replies to a comment. from: National Institute for Health and Care Excellence (NICE). Beta-blockers or calcium channel blockers are recommended as the first-line anti-anginal medicines.7 There Propranolol and atenolol have been studied most intensely in hypertension. bpac.org.nz/BPJ/2013/february/managing-heart-failure.aspx. While both drugs are used to treat heart-related issues, their applications are very different. You can still add a fresh comment by scrolling to the bottom of the discussion and clicking the "Add a comment" button. Labetalol 100mg BID. 2023 The Regents of the University of California. -, Hypertens Res. doi: 10.1002/j.1552-4604.1990.tb03498.x. Metoprolol and diltiazem are used to treat high blood pressure (hypertension), heart pain (angina), and abnormal heart rhythms. Beta blockers aren t recommended as a first treatment if you have only high blood pressure. enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), diuretics or calcium channel blockers are associated BB,beta-blockers,carvedilol,bisoprolol,metoprolol tartrate Created Date: 12/12/2007 11:40:11 AM . Beta-blockers National Library of Medicine The initial dosage of metoprolol succinate ranges from 25-100 mg per day. Beta-blockers: their properties and use in hypertension. The site is secure. Yancy C, Jessup M, Bozkurt B, et al. Only monitoring data with valid data greater than or equal to (>=) 80 percent (%) was used for analysis. Federal government websites often end in .gov or .mil. Nebivolol (Bystolic), the uniquely well-tolerated beta-blocker, is now They also are sometimes used to treat conditions related to your brain and nervous system. with reduced renal function.3, 5 Lipid-soluble beta blockers, e.g. Each ABPM lasted for at least 24 hours. I.V. Beta-blockers | Prescribing information | Hypertension | CKS | NICE As mentioned, most patients can be initially switched to 6.25 mg or 12.5 mg b.i.d. Objective: Bisoprolol, carvedilol and nebivolol have been shown to be effective in the treatment of heart failure. Bangalore S, Makani H, Radford M, et al. Table 3 Equivalent dose of carvedilol with other beta-blockers. You should take metoprolol at the same View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Its chemical name is ()1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol succinate (2:1) (salt). Erdmann E. Safety and tolerability of beta-blockers: prejudices and reality. Bananas. Metoprolol (Lopressor)* 2.5 to 5 mg IV bolus over 2 minutes, up to 3 doses . Atenolol is available in 25 mg, 50 mg, and 100 mg tablets. Before Sotalol. Weight <85kg, heart failure (50mg total daily), Contraindicated in severe liver impairment. ST-Elevation Myocardial Infarction Guidelines Group, New Zealand Branch of Cardiac Society of Australia and New Zealand. bisoprolol may be preferred, Respiratory disease: cardioselective beta-blockers, e.g. elevated heart rate, but 47.5 mg may be required for a patient with a significantly elevated heart rate. . Epub 2021 Jun 9. Primary outcome measure was . Choosing to participate in a study is an important personal decision. Metoprolol succinate is an oral modified-release formulation taken once daily while most formulations of metoprolol tartrate These changes often are temporary. dose is reduced and the patients cardiac receptors and sympathetic nerve activity down-regulate.3, 26. The top 9 with the exception of Bystolic are all generic and therefore relatively inexpensive. Beta-blockers that treatment was modified by reducing the first doses of metoprolol to 50 mg of metoprolol, equivalent to 25 mg of carvedilol. 2013 ACCF/AHA Guideline for the Management of Heart Failure. Elderly: Oral: Initial: 25 mg/day; usual range: 25-300 mg/day. Lexi-Comp, Inc. (Lexi-Drugs). The first dynamic daytime blood pressure monitoring was used as baseline. Beta blockers may not work as effectively for black people and older people, especially when taken without other blood pressure medications. Atenolol is also a prescription drug that is classified as cardioselective beta-1-selective adrenergic agonist. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Metoprolol tartrate vs. metoprolol succinate - Medical News Today in Collaboration With EACTS. Am. The difference between the daytime heart rate at Week 12 treatment and of the baseline heart rate was calculated to measure the change of mean ambulatory daytime heart rate at the end of the treatment. Sotalol should not be used for rate control in atrial fibrillation due to its pro-arrhythmic action. All beta-blockers produce competitive antagonism of beta-adrenoceptors in the autonomic nervous system.3 This Bisoprolol is processed by both the liver and kidneys therefore does not require dose adjustments for patients with 20mg/day (HTN) 10mg/day (HF) Disclaimer: Starting doses and titration schedule depend on individual clinical scenario and are particularly important to review with renal failure that may have different starting dose recommendations*. Moderate EH patients who have used anti-hypertension drugs, Subjects with history of coronary heart disease, Cerebrovascular events within 6 months before screening, Impaired hepatic or renal function (according to local lab standard), Other protocol defined exclusion criteria could apply. Pulse rate was measured by palpation on radial artery for 1 minute. Carvedilol 12.5 mg PO BID [immediate release] Carvedilol 40 mg PO DAILY [extended release] Labetalol 100 mg PO BID. The chemical name for the active ingredient in BYSTOLIC (nebivolol) tablets is (1RS,1RS)-1,1- [ (2RS,2SR)-bis (6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]- 2,2-iminodiethanol hydrochloride. The SWORD Investigators. Garlic. 608 ratings on Drugs.com. . ACE inhibitors interfere with the conversion of . Each ABPM lasted for at least 24 hours. 1990 Feb;30(S2):S61-5. The participants then received Metoprolol at a dose of 50 mg daily for 4 weeks, followed by 100 mg daily for another 4 weeks (i.e., weeks 9-16 in total). Study record managers: refer to the Data Element Definitions if submitting registration or results information. Bisoprolol. PDF Starting DoSe titration target DoSe - Gov 8 months and the mean daily dose of . Low-fat dairy products. Metoprolol and Bisoprolol. 02. ACE Inhibitor Conversion Table | Hospital Handbook Zealand before alternative options, e.g. 40mg/day. Beta-blockers are the first-line treatment for long-term symptomatic rate control in patients with a range of cardiac 8600 Rockville Pike . The difference between the mean ambulatory DBP observed in the last 4 hours after 12-week treatment and baseline was calculated to find out the change of mean ambulatory DBP at the end of the treatment. 03. Finally mean heart rate was recorded. British Hypertension Society. Water-soluble beta-blockers, e.g. 2016. 2.5 mg. 2.5-10mg. 500 mg QID/q6h. This can be increased to a maximum of 360 mg/day in divided doses. This selectivity is reduced at higher doses so the lowest effective dose should be used. The difference between the nighttime heart rate at Week 12 treatment and of the baseline heart rate was calculated to measure the change of mean ambulatory nighttime heart rate at the end of the treatment. In addition, the appropriate dosage . Non-selective beta-blockers, e.g. Doctors usually prescribe beta-blockers to treat cardiovascular conditions such as angina and hypertension, which is also known as high blood pressure. Receptor (s) affected: 1 Selective. Sotalol is used 1997 Jun;22(3):171-9. doi: 10.1046/j.1365-2710.1997.8775087.x. Full Answer. which included 15 studies with a follow-up period ranging from one to seven years found that beta-blockers in patients No significant clinical decisions should be made based on these images from this website without first consulting with a board-certified attending physician. Bisoprolol or metoprolol; consider withdrawal after 6-12 months if re-vascularised and no other indications. Listing a study does not mean it has been evaluated by the U.S. Federal Government. . Up to 5 mg, dose to be given at a rate of 1-2 mg/minute, then up to 5 mg after 5 minutes if required, total dose of 10-15 mg. 2011. Prescriber 2010;5. The drug is selective for beta-1 receptors. www.goodfellowunit.org/podcast/rational-use-beta-blockers-linda-bryant. Lopressor (metoprolol tartrate) lowers high blood pressure, controls chest pain, and helps treat heart failure and heart attack. may be improved with a slow upward titration of the beta-blocker until the maintenance dose is established. 2.3k views Reviewed >2 years ago. amlodipine. Atenolol 50mg daily. bisoprolol and metoprolol succinate, are less likely to cause fatigue and cold extremities Additional Resources - University of Maryland, Baltimore MeSH Teichert M, de Smet PAGM, Hofman A, et al. tachycardia. In 2016, 325 000 people received a beta-blocker from a community pharmacy in New Zealand:1, This pattern of prescribing is different to other countries, such as Australia where less than 5% of patients are Chest 2014;145:77986. Acebutolol 100 mg PO BID. service delivery areas, and we are recognised nationally and internationally for our expertise and innovation. Newer beta blockers, such as carvedilol (Coreg), dont usually cause weight gain as a side effect. Epub 2019 Apr 11. . The recent disruption of the supply of metoprolol succinate where dispensing was limited to fortnightly or monthly amounts Efficacy & tolerability of bisoprolol in comparison to metoprolol in the dose to every second day for another month, before stopping treatment completely at the time when the patients next The benefits of beta-blockers post-myocardial infarction are also no longer to those with co-existing heart failure;23 cardioselective beta-blockers are preferred. These include: Your email address will not be published. They have subtle differences but basically do the same things. Fish, garlic, berries, and certain vitamins and amino acids are all natural sources of beta-blockers. Available for Android and iOS devices. carvedilol or 100 mg metoprolol. The adverse effect profile varies between beta-blockers according to their properties (Table 1). Nighttime was defined as 10:00 pm to 06:00 am. Sotalol should be initiated and doses increased in a hospital with facilities for cardiac rhythm monitoring and assessment. Adverse respiratory effect of acute -blocker exposure in asthma: a systematic (or into if currently out) all comment notification emails by clicking the button below. (HF-REF) after a diuretic has reduced the patients fluid overload. Appendices > 03. If someone adds a reply to one of your comments (or replies) you will recieve an email notifying you of this. How Does Atenolol Compare to Metoprolol? - GoodRx Unable to load your collection due to an error, Unable to load your delegates due to an error. For atrial fibrillation, the starting dose of the beta-blocker depends on the patients heart rate Among these patients, the risk of mortality was not significantly different between carvedilol and metoprolol users (aHR, 0.97 [95% CI, 0.72-1.30]) . and may cause more bradycardia. 2014 Feb;23(1):3-16 Nighttime in this study was defined as 10:00 pm to 06:00 am. Each ABPM lasted for at least 24 hours. Is not subject to the Controlled Substances Act. review and meta-analysis of randomized controlled trials. Metoprolol vs. diltiazem - MedicineNet and then up-titrated at 12 week intervals (Table I). For secondary prevention of myocardial infarction, the evidence is best for timolol. Bisoprolol: Dosing of bisoprolol for patients with congestive heart failure is best guided by the CIBIS II dosing protocol. Guidelines recommend beta blocker therapy for three years, but that may not be necessary. Here is a 2017 chart of the most popular beta-blockers. 25 After 20 minutes, the acute vitamin C infusion was maintained at the same rate while the bradykinin and sodium . and transmitted securely. of which varies within each class. They are sub-classified into into selective and non-selective agents: Selective ( 1 antagonism) (BEAM) Bisoprolol. Brand Names: N/A. Unauthorized use of these marks is strictly prohibited. Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology]. diltiazem. after myocardial infarction.11 Alternatives disease. heart failure.14 Bisoprolol or metoprolol succinate are usually prescribed as they are the most cardioselective to persist with treatment as long as their systolic blood pressure does not fall too low, e.g. This item is 5 years and 8 months old; some content may no longer be current. Beta-blockers for cardiovascular conditions: one size does not - bpac By intravenous injection. Brand names: Cardicor, Congescor. Bisoprolol is reported to be more cardioselective than metoprolol and atenolol.4, Vasodilating beta-blockers, e.g. pressure (SBP) 140-159 mm Hg or diastolic blood pressure (DBP) 90-99 mm Hg were randomly assigned to receive either Bisoprolol 5 mg once daily or Metoprolol-SR 50 mg once daily. bisoprolol and metoprolol, Beta Blocker approximate dose equivalents Carvedilol The ABPM determined blood pressure once hourly in the nighttime. Zebeta (Bisoprolol) Prescription only. If Drug Comparisons Beta Blockers - Comparative properties and equivalent dosages of various beta blocker medications and protocols for clinical professionals. Beta Blocker Comparison: Which Is the Best One? - GoodRx bisoprolol and metoprolol, are preferred, All beta-blockers are considered to be equally effective (as fourth-line treatment). Beta blockers work by blocking the effects of the hormone epinephrine , also known as adrenaline. Celiprolol and pindolol have intrinsic sympathomimetic activity (ISA) and therefore simultaneously dosed once-daily and it is cardioselective (see below). There is, however, little evidence to support the systematic use of metoprolol succinate over other medicines in this class. less than 100 mmHg. Metoprolol succinate is available as an extended-release tablet, which means that people only have to take one tablet a day. and co-morbidities, e.g. There may be variations in CSA schedules between individual states. The role of the new beta-blockers in treating cardiovascular disease. Learn how we can help. Beta blockers also help open up your veins and arteries to improve blood flow. Metoprolol 1,2 bronchospasm IV 2.5-5 mg bolus over 2 min, up to 3 doses N/A hypotension, heart block, bradycardia, , HF succinate ER 25 See black box warnings for this drug Oral 25-100 mg twice daily. For other conditions, 3 5% of patients can be expected to be intolerant to beta-blocker treatment due to hypotension or bradycardia.20. Each ABPM lasted for at least 24 hours. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. You can't miss doses. From what my doctor told me, 12,5 mg of Metoprolol is similar . In the long-term, the Detailed Description. Bisoprolol has an average rating of 2016. . processes. Finally mean heart rate was recorded. Celiprolol Metoprolol tartrate, also known by the brand name Lopressor, is an immediate-release oral tablet that comes in strengths of 25 mg, 37.5 mg, 50 mg, 75 mg, and 100 mg. Metoprolol succinate, also known by the brand name Toprol XL, is an extended-release oral tablet that comes in strengths of 25 mg, 50 mg, 100 mg, and 200 mg. RELATED: Metoprolol vs . Commonly reported side effects include: See also: metoprolol side effects in more detail. metoprolol succinate 23.75 mg is equal to metoprolol If the patients blood pressure is on target, Only monitoring data with valid data >=80% was used for analysis. The following doses are equivalent to carvedilol 12.5mg BID acebutolol 100mg BID metoprolol 50mg BID propranolol 40mg BID . The ABPM determined blood pressure 3 times hourly in the daytime and once hourly in the nighttime. The dose conversion ratio of carvedilol to bisoprolol was 4.15 to 1 on average. Drugs R D. 2014 Dec;14(4):325-32. doi: 10.1007/s40268-014-0073-5. However, if you were taking 25 mg of atenolol, it makes sense that you would be initiated on a low dose of metoprolol succinate, around 25 to 50 mg. In people who have diabetes, beta blockers may block signs of low blood sugar, such as rapid heartbeat. Saffron. This site complies with the HONcode standard for trust- worthy health information: verify here. an asthma attack. Subjects will receive bisoprolol fumarate (Concor) at a dose of 5 milligram (mg) once daily orally as sustained release (SR) tablets for a period of 4 weeks. In addition to blocking 1 receptors, non-selective beta blockers also block beta-2 (2) receptors in the body. Metoprolol vs Propranolol Comparison - Drugs.com (number needed to treat [NNT] 26) and the risk of recurrent myocardial infarction (NNT 209).17. Beta-Blockers for Anxiety: Benefits, Side Effects, and Risks - Healthline are immediate-release,* taken twice daily. government site. Bisoprolol 1.25 mg PO daily 10 mg PO daily . low blood sugar. A 200 mg modified-release form of metoprolol tartrate, taken once daily, is available fully subsidised in New Zealand. At 612-months post-myocardial infarction prescribers are encouraged to consider withdrawing beta-blockers from patients Timolol 5mg BID. Metoprolol Tartrate vs. Metoprolol Succinate: A Comparison - Healthline What is the difference between bisoprolol and metoprolol? Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01508325. reduce resting heart rate less than others (due to ISA) tend not to be used for angina, e.g. The dose of bisoprolol will be escalated to 7.5 mg orally once daily for next 4 weeks (Weeks 4 to 8) and to 10 mg orally once daily for the next 4 weeks (Weeks 8 to 12), if clinic systolic blood pressure (SBP) was greater than or equal to (>=) 140 millimeters of mercury (mmHg) and/or diastolic blood pressure (DBP) was >=90 mmHg measured every 4 . (Clinical Trial), Comparison of Bisoprolol With Metoprolol Succinate Sustained-release on Heart Rate and Blood Pressure in Hypertensive Patients (CREATIVE Study), 18 Years to 70 Years (Adult, Older Adult), To compare the efficacy of the 2 study drugs by 24h ambulatory monitoring by several parameters at different times (Example: blood pressure, heart rate, their variability, etc) after 12-week treatment from baseline among subjects with mild to moderate EH, To evaluate the treatment compliance of the two drugs, Change From Baseline in Mean Ambulatory Diastolic Blood Pressure (DBP) in the Last 4 Hours After 12-week Treatment [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Heart Rate in the Last 4 Hours After 12-week Treatment [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Ambulatory Systolic Blood Pressure (SBP) in the Last 4 Hours After 12-week Treatment [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Ambulatory 24-hour Blood Pressure at Week 12 [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Ambulatory Daytime Blood Pressure at Week 12 [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Ambulatory Night-time Blood Pressure at Week 12 [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Ambulatory Daytime Heart Rate at Week 12 [TimeFrame:Baseline and Week 12], Change From Baseline in Mean Ambulatory Night-time Heart Rate at Week 12 [TimeFrame:Baseline and Week 12], Change From Baseline in 24-hour Blood Pressure Variability at Week 12 [TimeFrame:Baseline and Week 12], Blood Pressure Response Rate [TimeFrame:Week 12], Heart Rate Response Rate [TimeFrame:Week 12], Change From Baseline in Mean Ambulatory 24-hour Heart Rate at Week 12 [TimeFrame:Baseline and Week 12], Subjects aged: >=18 years and =<70 years old.

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